• Login
    View Item 
    •   NRU
    • Journal Publications
    • Social Sciences
    • Social Sciences
    • View Item
    •   NRU
    • Journal Publications
    • Social Sciences
    • Social Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection

    Thumbnail
    View/Open
    Article (2.424Mb)
    Date
    2016
    Author
    Demers, Korey R.
    Makedonas, George
    Buggert, Marcus
    Eller, Michael A.
    Ratcliffe, Sarah J.
    Goonetilleke, Nilu
    Li, Chris K.
    Anne Eller, Leigh
    Rono, Kathleen
    Maganga, Lucas
    Nitayaphan, Sorachai
    Kibuuka, Hannah
    Routy, Jean-Pierre
    Slifka, Mark K.
    Haynes, Barton F.
    McMichael, Andrew J.
    Bernard, Nicole F.
    Robb, Merlin L.
    Betts, Michael R.
    Metadata
    Show full item record
    Abstract
    The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8+ T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin+ CD8+ T cells immediately following HIV infection that quickly waned after acute viremia resolution. Selective expression of the effector-associated transcription factors T-bet and eomesodermin in cytokine-producing HIV-specific CD8+ T cells differentiated HIV-specific from bulk memory CD8+ T cell effector expansion. As infection progressed expression of perforin was maintained in HIV-specific CD8+ T cells with high levels of T-bet, but not necessarily in the population of T-betLo HIV-specific CD8+ T cells that expand as infection progresses. Together, these data demonstrate that while HIV-specific CD8+ T cells in acute HIV infection initially possess cytolytic potential, progressive transcriptional dysregulation leads to the reduced CD8+ T cell perforin expression characteristic of chronic HIV infection.
    URI
    https://nru.uncst.go.ug/handle/123456789/6340
    Collections
    • Social Sciences [934]

    Research Dissemination Platform copyright © since 2021  UNCST
    Contact Us | Send Feedback
    Partners
     

     

    Browse

    All of NRU
    Communities & CollectionsBy Issue DateAuthorsTitlesSubjects
    This Collection
    By Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Research Dissemination Platform copyright © since 2021  UNCST
    Contact Us | Send Feedback
    Partners