Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection

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dc.contributor.authorDemers, Korey R.
dc.contributor.authorMakedonas, George
dc.contributor.authorBuggert, Marcus
dc.contributor.authorEller, Michael A.
dc.contributor.authorRatcliffe, Sarah J.
dc.contributor.authorGoonetilleke, Nilu
dc.contributor.authorLi, Chris K.
dc.contributor.authorAnne Eller, Leigh
dc.contributor.authorRono, Kathleen
dc.contributor.authorMaganga, Lucas
dc.contributor.authorNitayaphan, Sorachai
dc.contributor.authorKibuuka, Hannah
dc.contributor.authorRouty, Jean-Pierre
dc.contributor.authorSlifka, Mark K.
dc.contributor.authorHaynes, Barton F.
dc.contributor.authorMcMichael, Andrew J.
dc.contributor.authorBernard, Nicole F.
dc.contributor.authorRobb, Merlin L.
dc.contributor.authorBetts, Michael R.
dc.date.accessioned2022-12-15T18:56:25Z
dc.date.available2022-12-15T18:56:25Z
dc.date.issued2016
dc.description.abstractThe loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8+ T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin+ CD8+ T cells immediately following HIV infection that quickly waned after acute viremia resolution. Selective expression of the effector-associated transcription factors T-bet and eomesodermin in cytokine-producing HIV-specific CD8+ T cells differentiated HIV-specific from bulk memory CD8+ T cell effector expansion. As infection progressed expression of perforin was maintained in HIV-specific CD8+ T cells with high levels of T-bet, but not necessarily in the population of T-betLo HIV-specific CD8+ T cells that expand as infection progresses. Together, these data demonstrate that while HIV-specific CD8+ T cells in acute HIV infection initially possess cytolytic potential, progressive transcriptional dysregulation leads to the reduced CD8+ T cell perforin expression characteristic of chronic HIV infection.en_US
dc.identifier.citationDemers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, et al. (2016) Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. PLoS Pathog 12(8): e1005805. doi:10.1371/journal. ppat.1005805en_US
dc.identifier.other10.1371/journal. ppat.1005805
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6340
dc.language.isoenen_US
dc.publisherPLOS Pathogensen_US
dc.subjectTemporal Dynamicsen_US
dc.subjectCD8+ T Cellen_US
dc.subjectPrimary HIV Infectionen_US
dc.titleTemporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infectionen_US
dc.typeArticleen_US
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