Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry

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dc.contributor.authorGumbi, Bhekumuzi P.
dc.contributor.authorMoodley, Brenda
dc.contributor.authorBirungi, Grace
dc.contributor.authorNdungu, Patrick G.
dc.date.accessioned2022-12-29T09:49:30Z
dc.date.available2022-12-29T09:49:30Z
dc.date.issued2017
dc.description.abstractA method was optimized for derivatization, separation, detection and quantification of salicylic acid, acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and diclofenac in surface water using gas chromatography-mass spectrometry. For most of the acidic drugs, recovery was in the range 60e110% and the percent standard deviation was below 15% for the entire method, with limits of detection ranging from 0.041 to 1.614 mg L-1. The developed method was applied in the analysis of acidic drugs in Umgeni River system, KwaZulu-Natal South Africa. All of the selected acidic drugs were detected and quantified, their concentration in Umgeni River system ranged from 0.0200 to 68.14 mg L-1.en_US
dc.identifier.citationGumbi, B.P., et al., Detection and quantification of acidic drug residues in South African surfacewater using gas chromatography-mass spectrometry, Chemosphere (2016), http://dx.doi.org/10.1016/j.chemosphere.2016.10.105en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.chemosphere.2016.10.105
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6717
dc.language.isoenen_US
dc.publisherChemosphereen_US
dc.subjectAcidic drugsen_US
dc.subjectMethod validationen_US
dc.subjectDerivatizationen_US
dc.subjectGC-MSen_US
dc.subjectSurface wateren_US
dc.subjectUmgeni riveren_US
dc.titleDetection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometryen_US
dc.typeArticleen_US
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