Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Chemosphere
Abstract
A method was optimized for derivatization, separation, detection and quantification of salicylic acid,
acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and
diclofenac in surface water using gas chromatography-mass spectrometry. For most of the acidic drugs,
recovery was in the range 60e110% and the percent standard deviation was below 15% for the entire
method, with limits of detection ranging from 0.041 to 1.614 mg L-1. The developed method was applied
in the analysis of acidic drugs in Umgeni River system, KwaZulu-Natal South Africa. All of the selected
acidic drugs were detected and quantified, their concentration in Umgeni River system ranged from
0.0200 to 68.14 mg L-1.
Description
Keywords
Acidic drugs, Method validation, Derivatization, GC-MS, Surface water, Umgeni river
Citation
Gumbi, B.P., et al., Detection and quantification of acidic drug residues in South African surfacewater using gas chromatography-mass spectrometry, Chemosphere (2016), http://dx.doi.org/10.1016/j.chemosphere.2016.10.105