In search of new anticancer drugs: Data for cytotoxic activities of green synthesized silver nanoparticles from ethanolic extracts of fruits and leaves of Annona muricata and 5- Fluorouracil against HeLa, PC3 and PNT1A cell lines
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Date
2019
Journal Title
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Data in brief
Abstract
In this article, we present data on the anticancer activities of green
synthesized silver nanoparticles (AgNPs) from ethanolic extracts of
fruits (AgNPs-F) and leaves (AgNPs-L) of Annona muricata and
standard anticancer drug 5-Fluorouracil (5-FU) on two cancer cell
lines, i.e. cervical adenocarcinoma (HeLa cells) and prostate
adenocarcinoma (PC3 cells) as well as on an immortalized normal
prostate cell line, PNT1A. The cytotoxicity on the cells was determined
by measuring the absorbance signal of resazurin dye. It has long been known that metabolically active cells change the resazurin
from blue (oxidized) to red (reduced) forms, corresponding
to the absorbance signals at a wavelength of 570nm (A570) and
600nm (A600) respectively, from which therefore the effects of any
treatments on percentage cell viability/death can be elucidated.
The raw data values of the treatments against the HeLa, PC3 and
PNT1A cells are shown in the different Tables. Examples of how the
data can be analyzed have been illustrated using different growth
inhibition curves. The data can be used by academics, students,
and researchers working on development of anticancer drugs.
Description
Keywords
Silver nanoparticles (AgNPs), 5FU
Citation
Gavamukulya, Y., Maina, E. N., Meroka, A. M., El-Shemy, H. A., Magoma, G., & Wamunyokoli, F. (2019). In search of new anticancer drugs: Data for cytotoxic activities of green synthesized silver nanoparticles from ethanolic extracts of fruits and leaves of Annona muricata and 5-Fluorouracil against HeLa, PC3 and PNT1A cell lines. Data in brief, 26, 104442. https://doi.org/10.1016/j.dib.2019.104442