Effect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of Wistar albino rats

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dc.contributor.authorMonima, Lemuel Ann
dc.contributor.authorBuhari, Muhammad
dc.contributor.authorLawal, Sodiq
dc.contributor.authorEchoru, Isaac
dc.contributor.authorSsempijja, Fred
dc.contributor.authorOwembabazi, Elna
dc.contributor.authorBukenya, Edmund
dc.contributor.authorMario Edgar, Fernandez Diaz
dc.contributor.authorArchibong Victor, Bassey
dc.contributor.authorKokas, Ikwap
dc.date.accessioned2023-05-15T17:28:20Z
dc.date.available2023-05-15T17:28:20Z
dc.date.issued2019
dc.description.abstractCleome gynandra is a medicinal plant that is used all over Uganda to hasten childbirth because, it possesses the ability to contract the uterus. It is also used as an abortifacient in the first trimester. In this study, the effects of Cleome gynandra were investigated on the estrous cycle and the histology of the ovary and uterus of adult Wistar rat. Twelve adult female Wistar rats of 130-140g average weight were used. These were divided into three groups of four animals each. Group A received distilled water only, while animals in groups B and C received 250mg/kg body weight and 500mg/kg body weight of extract, orally and daily respectively. Monitoring of estrous cycle continued throughout the three weeks of extract administration. After three weeks, the ovaries and uteri were excised and processed for histological examination. In the ovary, there was a reduction in number of primordia, primary, secondary and graafian follicles in the treated groups. Vacuolations were common to both the ovarian and uterine tissues of treated animals. The estrous cycle of Group B and C, showed a mild disruption when compared to animals in Group A. The results showed that the plant extract studied, exerted negative influences on the estrous cycle and histology of the ovary and uterus of Wistar albino rats, suggesting a disturbance on the reproductive health of the animals. Further studies to determine the mechanism of action of Cleome gynandra on the ovary and uterus and the levels of FSH, LH, estradiol and progesterone is recommended.en_US
dc.identifier.citationMonima, L. A., Buhari, M., Lawal, S., Isaac, E., Fred, S., Elna, O., ... & Ikwap, K. (2019). Effect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of Wistar albino rats. Anatomy Journal of Africa, 8(1), 1385-1394.en_US
dc.identifier.urihttps://www.ajol.info/index.php/aja/article/view/182619
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8702
dc.language.isoenen_US
dc.publisherAnatomy Journal of Africaen_US
dc.subjectCleome gynandraen_US
dc.subjectEstrous cycleen_US
dc.subjectWistar albino ratsen_US
dc.subjectOvarian folliclesen_US
dc.titleEffect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of Wistar albino ratsen_US
dc.typeArticleen_US
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