Effect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of Wistar albino rats
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Anatomy Journal of Africa
Abstract
Cleome gynandra is a medicinal plant that is used all over Uganda to hasten childbirth because, it
possesses the ability to contract the uterus. It is also used as an abortifacient in the first trimester.
In this study, the effects of Cleome gynandra were investigated on the estrous cycle and the
histology of the ovary and uterus of adult Wistar rat. Twelve adult female Wistar rats of 130-140g
average weight were used. These were divided into three groups of four animals each. Group A
received distilled water only, while animals in groups B and C received 250mg/kg body weight and
500mg/kg body weight of extract, orally and daily respectively. Monitoring of estrous cycle continued
throughout the three weeks of extract administration. After three weeks, the ovaries and uteri were
excised and processed for histological examination. In the ovary, there was a reduction in number
of primordia, primary, secondary and graafian follicles in the treated groups. Vacuolations were
common to both the ovarian and uterine tissues of treated animals. The estrous cycle of Group B
and C, showed a mild disruption when compared to animals in Group A. The results showed that the
plant extract studied, exerted negative influences on the estrous cycle and histology of the ovary and
uterus of Wistar albino rats, suggesting a disturbance on the reproductive health of the animals.
Further studies to determine the mechanism of action of Cleome gynandra on the ovary and uterus
and the levels of FSH, LH, estradiol and progesterone is recommended.
Description
Keywords
Cleome gynandra, Estrous cycle, Wistar albino rats, Ovarian follicles
Citation
Monima, L. A., Buhari, M., Lawal, S., Isaac, E., Fred, S., Elna, O., ... & Ikwap, K. (2019). Effect of Cleome gynandra leaf extract on the estrous cycle and histology of the ovary and uterus of Wistar albino rats. Anatomy Journal of Africa, 8(1), 1385-1394.