Anti-nociceptive activity of the ethanol extract of Eucalyptus globulus leaf in experimental animals
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pharmacognosy and Phytochemistry
Abstract
Eucalyptus globulus has been used in African folklore for the treatment of several disease conditions like
pain, fever and inflammation. The aim of the present study was to investigate the anti-nociceptive
properties of Eucalyptus globulus and the probable mechanism using thermal and chemical models of
nociception.
Acute toxicity revealed no mortality in the mice up to a dose of 5,000 mg/kg. The phytochemistry
revealed the presence of alkaloids, flavonoids, saponins, tannins, cardiac glycosides and terpenoids. The
extract significantly reduced pain as compared to control in the thermal and chemical models of pain
employed in this study through mechanism that may involve the L-Type Voltage gated Calcium channel
but ruled out the involvement of the adrenergic system and ATP sensitive K+
channel. Moreover the anti-
nociceptive activities demonstrated by the extract in this study might be due to the phytochemicals
revealed in the extract.
Description
Keywords
Anti-nociception, Eucalyptus globulus, Calcium channel, Formalin, Analgesic, Phytochemistry
Citation
Owemidu, I. O., Taiwo, A. A., Dangana, E. O., Jonah, C. A., Negedu, M. N., Suleiman, H. O., & Odoma, S. (2020). Anti-nociceptive activity of the ethanol extract of Eucalyptus globulus leaf in experimental animals. Journal of Pharmacognosy and Phytochemistry, 9(4), 3446-3451.