Anti-nociceptive activity of the ethanol extract of Eucalyptus globulus leaf in experimental animals

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dc.contributor.authorOlumorin Owemidu, Idowu
dc.contributor.authorAbraham Taiwo, Abayomi
dc.contributor.authorOjochebo Dangana, Elizabeth
dc.contributor.authorAchile Jonah, Caleb
dc.contributor.authorNafiu Negedu, Muhammed
dc.contributor.authorOzovehe Suleiman, Haruna
dc.contributor.authorOdoma, Saidi
dc.date.accessioned2023-07-04T06:09:05Z
dc.date.available2023-07-04T06:09:05Z
dc.date.issued2020
dc.description.abstractEucalyptus globulus has been used in African folklore for the treatment of several disease conditions like pain, fever and inflammation. The aim of the present study was to investigate the anti-nociceptive properties of Eucalyptus globulus and the probable mechanism using thermal and chemical models of nociception. Acute toxicity revealed no mortality in the mice up to a dose of 5,000 mg/kg. The phytochemistry revealed the presence of alkaloids, flavonoids, saponins, tannins, cardiac glycosides and terpenoids. The extract significantly reduced pain as compared to control in the thermal and chemical models of pain employed in this study through mechanism that may involve the L-Type Voltage gated Calcium channel but ruled out the involvement of the adrenergic system and ATP sensitive K+ channel. Moreover the anti- nociceptive activities demonstrated by the extract in this study might be due to the phytochemicals revealed in the extract.en_US
dc.identifier.citationOwemidu, I. O., Taiwo, A. A., Dangana, E. O., Jonah, C. A., Negedu, M. N., Suleiman, H. O., & Odoma, S. (2020). Anti-nociceptive activity of the ethanol extract of Eucalyptus globulus leaf in experimental animals. Journal of Pharmacognosy and Phytochemistry, 9(4), 3446-3451.en_US
dc.identifier.issn2278-4136
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9038
dc.language.isoenen_US
dc.publisherJournal of Pharmacognosy and Phytochemistryen_US
dc.subjectAnti-nociceptionen_US
dc.subjectEucalyptus globulusen_US
dc.subjectCalcium channelen_US
dc.subjectFormalinen_US
dc.subjectAnalgesicen_US
dc.subjectPhytochemistryen_US
dc.titleAnti-nociceptive activity of the ethanol extract of Eucalyptus globulus leaf in experimental animalsen_US
dc.typeArticleen_US
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