P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population

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P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population.pdf (145.33 KB)
Date
2009
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Publisher
Retrovirology
Abstract
We previously reported slow HIV-1 disease progression in this population to be associated with the inherent host HLA B allele-mediated ability to induce broader Gag T-cell responses and faster disease progression to be more associated with clade D than A. Since Gag escape mutations often reduce viral fitness leading to significant reduction in virus replication, in this study, we evaluated the immunogenetic characteristics of clades A and D-associated escape mutations that could be harnessed for vaccine design.
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Keywords
Viral Fitness, Substitution A163G, Fast Disease Progression, Ugandan Population, Immunogenetic Characteristic
Citation
Serwanga, J., Ndembi, N., Nanteza, B., Mugaba, S., Pimego, E., Pala, P., ... & Kaleebu, P. (2009). P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population. Retrovirology, 6(3), 1-1.https://doi.org/10.1186/1742-4690-6-S3-P380
URI
https://nru.uncst.go.ug/handle/123456789/8086
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Medical and Health Sciences