P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population

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dc.contributor.authorSerwanga, J.
dc.contributor.authorNdembi, N.
dc.contributor.authorNanteza, B.
dc.contributor.authorMugaba, S.
dc.contributor.authorPimego, E.
dc.contributor.authorPala, P.
dc.contributor.authorAuma, B.
dc.contributor.authorLyagoba, F.
dc.contributor.authorKaleebu, P.
dc.date.accessioned2023-03-06T17:01:14Z
dc.date.available2023-03-06T17:01:14Z
dc.date.issued2009
dc.description.abstractWe previously reported slow HIV-1 disease progression in this population to be associated with the inherent host HLA B allele-mediated ability to induce broader Gag T-cell responses and faster disease progression to be more associated with clade D than A. Since Gag escape mutations often reduce viral fitness leading to significant reduction in virus replication, in this study, we evaluated the immunogenetic characteristics of clades A and D-associated escape mutations that could be harnessed for vaccine design.en_US
dc.identifier.citationSerwanga, J., Ndembi, N., Nanteza, B., Mugaba, S., Pimego, E., Pala, P., ... & Kaleebu, P. (2009). P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population. Retrovirology, 6(3), 1-1.https://doi.org/10.1186/1742-4690-6-S3-P380en_US
dc.identifier.issn1742-4690
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8086
dc.language.isoenen_US
dc.publisherRetrovirologyen_US
dc.subjectViral Fitnessen_US
dc.subjectSubstitution A163Gen_US
dc.subjectFast Disease Progressionen_US
dc.subjectUgandan Populationen_US
dc.subjectImmunogenetic Characteristicen_US
dc.titleP20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan populationen_US
dc.typeArticleen_US
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