Prevalence of anaemia and associated factors among people with pulmonary tuberculosis in Uganda
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Epidemiology & Infection
Abstract
Anaemia predicts delayed sputum conversion and mortality in tuberculosis (TB). We determined
the prevalence and factors associated with anaemia among people with TB at the
National Tuberculosis Treatment Centre in Uganda. People with bacteriologically confirmed
TB were consecutively enrolled in a cross-sectional study between August 2017 and March
2018. Blood samples were tested for a full blood hemogram, HIV infection, and CD4+ and
CD8+ T-cell counts. Anaemia was defined as a haemoglobin level of <13.0 grams per decilitre
(g/dl) for males and <12.0 g/dl for females. Of 358 participants, 210 (58.7%, 95% confidence
interval (CI) 53.4–63.8) had anaemia. Anaemia was associated with night sweats, a longer duration
of fever, low body mass index (BMI), hyperthermia, high sputum bacillary loads, HIV
co-infection, and low CD4 and CD8 counts at bivariate analysis. Factors associated with
anaemia at multivariable analysis were low BMI (odds ratio (OR) 2.93, 95% CI 1.70–5.05,
P < 0.001), low CD4:CD8 ratio (OR 2.54, 95% CI 1.07–6.04, P = 0.035) and microcytosis
(OR 4.23, 95% CI 2.17–8.25, P < 0.001). Anaemia may be associated with the features of severe
TB disease and should be considered in TB severity scores.
Description
Keywords
Anaemia, Immunity, Nutrition, Severity, Tuberculosis
Citation
Baruch Baluku J, Mayinja E, Mugabe P, Ntabadde K, Olum R, Bongomin F (2022). Prevalence of anaemia and associated factors among people with pulmonary tuberculosis in Uganda. Epidemiology and Infection 150, e29, 1–8. https://doi.org/ 10.1017/S0950268822000103