Prevalence of anaemia and associated factors among people with pulmonary tuberculosis in Uganda

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dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorMayinja, Ernest
dc.contributor.authorMugabe, Pallen
dc.contributor.authorNtabadde, Kauthrah
dc.contributor.authorOlum, Ronald
dc.contributor.authorBongomin, Felix
dc.date.accessioned2023-01-24T11:19:51Z
dc.date.available2023-01-24T11:19:51Z
dc.date.issued2022
dc.description.abstractAnaemia predicts delayed sputum conversion and mortality in tuberculosis (TB). We determined the prevalence and factors associated with anaemia among people with TB at the National Tuberculosis Treatment Centre in Uganda. People with bacteriologically confirmed TB were consecutively enrolled in a cross-sectional study between August 2017 and March 2018. Blood samples were tested for a full blood hemogram, HIV infection, and CD4+ and CD8+ T-cell counts. Anaemia was defined as a haemoglobin level of <13.0 grams per decilitre (g/dl) for males and <12.0 g/dl for females. Of 358 participants, 210 (58.7%, 95% confidence interval (CI) 53.4–63.8) had anaemia. Anaemia was associated with night sweats, a longer duration of fever, low body mass index (BMI), hyperthermia, high sputum bacillary loads, HIV co-infection, and low CD4 and CD8 counts at bivariate analysis. Factors associated with anaemia at multivariable analysis were low BMI (odds ratio (OR) 2.93, 95% CI 1.70–5.05, P < 0.001), low CD4:CD8 ratio (OR 2.54, 95% CI 1.07–6.04, P = 0.035) and microcytosis (OR 4.23, 95% CI 2.17–8.25, P < 0.001). Anaemia may be associated with the features of severe TB disease and should be considered in TB severity scores.en_US
dc.identifier.citationBaruch Baluku J, Mayinja E, Mugabe P, Ntabadde K, Olum R, Bongomin F (2022). Prevalence of anaemia and associated factors among people with pulmonary tuberculosis in Uganda. Epidemiology and Infection 150, e29, 1–8. https://doi.org/ 10.1017/S0950268822000103en_US
dc.identifier.urihttps://doi.org/ 10.1017/S0950268822000103
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7150
dc.language.isoenen_US
dc.publisherEpidemiology & Infectionen_US
dc.subjectAnaemiaen_US
dc.subjectImmunityen_US
dc.subjectNutritionen_US
dc.subjectSeverityen_US
dc.subjectTuberculosisen_US
dc.titlePrevalence of anaemia and associated factors among people with pulmonary tuberculosis in Ugandaen_US
dc.typeArticleen_US
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