Prevalence of cardiovascular risk factors in active tuberculosis in Africa: a systematic review and meta‑analysis
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Reports
Abstract
People with tuberculosis (TB) are at risk of major adverse cardiovascular events. We estimated the
prevalence of cardiovascular risk (CVR) factors among people with active TB in Africa. This was a
systematic review and meta-analysis of studies from Africa. We searched EMBASE, MEDLINE through
PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, mRCTs, Clinical trials.gov,
and International Clinical Trials Registry Platform from inception to 31st December 2021. Among 110
eligible studies, 79 (238,316 participants) were included in the meta-analysis for smoking, 67 (52,793
participants) for current alcohol use, 30 (31,450 participants) for hazardous alcohol use, 51 (37,879
participants) for diabetes mellitus (DM), 19 (18,211 participants) for hypertension and 18 (13,910
participants) for obesity. The pooled prevalence was 26.0% (95% confidence interval 22.0–29.0) for
smoking, 30.0% (25.0–35.0) for any current alcohol use, 21.0% (17.0–26.0) for hazardous alcohol
use, 14.0% (9.0–18.0) for hypertension, 7.0% (6.0–9.0) for DM, and 4.0% (2.0–5.0) for obesity. Costeffective
strategies are needed to screen for CVR factors among people with active TB in Africa.
Description
Keywords
Cardiovascular risk factors, Tuberculosis, Africa
Citation
Baluku, J. B., Ronald, O., Bagasha, P., Okello, E., & Bongomin, F. (2022). Prevalence of cardiovascular risk factors in active tuberculosis in Africa: a systematic review and meta-analysis. Scientific Reports, 12(1), 16354. https://doi.org/10.1038/s41598-022-20833-0