Browsing by Author "Setshedi, Mashiko"

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    The Global Epidemiology of Viral-induced Acute Liver Failure: a systematic review protocol
    (BMJ open, 2019) Patterson, Jenna; Hussey, Hannah Sophia; Setshedi, Mashiko; Kagina, Benjamin; Muloiwa, Rudzani
    The burden of viral-induced acute liver failure (ALF) around the world still remains unclear, with little to no data collected regarding the disease incidence in general and synthesised data on the relative contribution of different viruses to the aetiology of ALF is missing in the field. The aim of this review is to estimate the burden (prevalence, incidence, mortality, hospitalisation) of ALF following infection HAV, HBV, HCV, HDV, HEV, EBV), HSV1, HSV2, VZV, parvo-virus B19, HPIVs, YFV, HVV-6, CMV, CA16 and/or HAdVs. Establishing the common aetiologies of viral-induced ALF, which vary geographically, is important so that: (1) treatment can be initiated quickly, (2) contraindications to liver transplant can be identified, (3) prognoses can be deterined more accurately, and most importantly, (4) vaccination against viral ALF aetiologies can be prioritised especially in under-resourced regions with public health risks associated with the relevant attributable diseases.
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    Systematic Review of the Global Epidemiology of Viral-induced Acute Liver Failure
    (BMJ open, 2020) Patterson, Jenna; Silal, Sheetal; Setshedi, Mashiko; Hussey, Gregory D.; Kagina, Benjamin M.; Muloiwa, Rudzani
    The aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention. Immunisation against hepatitis A and hepatitis B should be prioritised in low-income and middle-income countries to prevent high viral-induced acute liver failure mortality rates, especially in settings where resources for managing acute liver failure are lacking. The expanded use of hepatitis E immunisation should be explored as hepatitis E virus was the most common cause of acute liver failure.