The Global Epidemiology of Viral-induced Acute Liver Failure: a systematic review protocol
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
BMJ open
Abstract
The burden of viral-induced acute liver failure (ALF) around the world still remains unclear, with little to no data collected regarding the disease incidence in general and synthesised data on the relative contribution of different viruses to the aetiology of ALF is missing in the field. The aim of this review is to estimate the burden (prevalence, incidence, mortality, hospitalisation) of ALF following infection HAV, HBV, HCV, HDV, HEV, EBV), HSV1, HSV2, VZV, parvo-virus B19, HPIVs, YFV, HVV-6, CMV, CA16 and/or HAdVs. Establishing the common aetiologies of viral-induced ALF, which vary geographically, is important so that: (1) treatment can be initiated quickly, (2) contraindications to liver transplant can be identified, (3) prognoses can be deterined more accurately, and most importantly, (4) vaccination against viral ALF aetiologies can be prioritised especially in under-resourced regions with public health risks associated with the relevant attributable diseases.
Description
Keywords
acute liver failure, incidence, aetiologies
Citation
Patterson, J., Hussey, H. S., Abdullahi, L. H., Silal, S., Goddard, L., Setshedi, M., ... & Muloiwa, R. (2019). The global epidemiology of viral-induced acute liver failure: a systematic review protocol. BMJ open, 9(8), e029819.http://dx.doi.org/10.1136/bmjopen-2019-029819