Browsing by Author "Okoth, Felix"
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Item Intervention To Stop Transmission of Imported Pneumonic Plague — Uganda, 2019(Morbidity and Mortality Weekly Report, 2019) Apangu, Titus; Acayo, Sarah; Atiku, Linda A.; Apio, Harriet,; Candini, Gordian; Okoth, Felix; Kaggwa Basabose, John; Ojosia, Lawrence; Ajoga, Sam; Mongiba, Grace; Makoba Wetaka, Milton; Kayiwa, Joshua; Balinandi, Stephen; Schwartz, Amy; Yockey, Brook; Sexton, Christopher; Dietrich, Elizabeth A.; Pappert, Ryan; Petersen, Jeannine M.; Mead, Paul S.; Lutwama, Julius J.; Kugeler, Kiersten J.Plague, an acute zoonosis caused by Yersinia pestis, isendemic in the West Nile region of northwestern Uganda andneighboring northeastern Democratic Republic of the Congo(DRC) (1–4). The illness manifests in multiple clinical forms,including bubonic and pneumonic plague. Pneumonic plagueis rare, rapidly fatal, and transmissible from person to person via respiratory droplets. On March 4, 2019, a patient withsuspected pneumonic plague was hospitalized in West Nile,Uganda, 4 days after caring for her sister, who had come toUganda from DRC and died shortly thereafter, and 2 daysafter area officials received a message from a clinic in DRCwarning of possible plague. The West Nile-based Uganda Virus Research Institute (UVRI) plague program, together withlocal health officials, commenced a multipronged responseto suspected person-to-person transmission of pneumonicplague, including contact tracing, prophylaxis, and education.Plague was laboratoryconfirmed, and no additionaltransmission occurred in Uganda. This event transpired inthe context of heightened awareness of cross-border disease spread caused by ongoing Ebola virus disease transmission in DRC, approximately 400 km to the south. Building expertise in areas of plague endemicity can provide the rapid detection and effective response needed to mitigate epidemic spread and minimize mortality. Cross-border agreements can improve ability to respond effectively.Item Intervention To Stop Transmission of Imported Pneumonic Plague — Uganda, 2019(, 69(9),, 2020) Apangu, Titus; Acayo, Sarah; Atiku, Linda A.; Apio, Harriet; Candini, Gordian; Okoth, Felix; Basabose, John Kaggwa; Ojosia, Lawrence; Ajoga, Sam; Mongiba, Grace; Wetaka, Milton Makoba; Kayiwa, Joshua; Balinand, Stephen; Schwartz, Amy; Yockey, Brook; Sexton, Christopher; Dietrich, Elizabeth A.; Pappert, Ryan; Petersen, Jeannine M.; Mead, Paul S.; Lutwama, Julius J.; Kugeler, Kiersten J.A plague is an acute zoonosis that occurs on several continents and can manifest in different clinical forms. Pneumonic plague is highly fatal and directly transmissible from person to person via infectious respiratory droplets. Importation of pneumonic plague from the Democratic Republic of the Congo into an area of Uganda with effective public health response capabilities resulted in prompt action to halt transmission. Despite multiple high-risk exposures, only a single transmission event occurred. Building expertise in areas of plague endemicity can provide the rapid detection and response needed to mitigate the epidemic spread and minimize mortality. Cross-border agreements can improve ability to respond effectivelyItem Successful Treatment Of Human Plague With Oral Ciprofloxacin(Emerging infectious diseases, 2017) Apangu, Titus; Griffith, Kevin; Abaru, Janet; Candini, Gordian; Apio, Harriet; Okoth, Felix; Okello, Robert; Kaggwa, John; Acayo, Sarah; Ezama, Geoffrey; Yockey, Brook; Sexton, Christopher; Schriefer, Martin; Mbidde, Edward Katongole; Mead, PaulThe US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.Item Successful Treatment of Human Plague with Oral Ciprofloxacin(Emerging infectious diseases, 2017) Apangu, Titus; Griffith, Kevin; Abaru, Janet; Candini, Gordian; Apio, Harriet; Okoth, Felix; Okello, Robert; Kaggwa, John; Acayo, Sarah; Ezama, Geoffrey; Yockey, Brook; Sexton, Christopher; Schriefer, Martin; Katongole Mbidde, Edward; Mead, PaulThe US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.