Browsing by Author "Kerchan, Patrick"

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    EBV & HHV8 and HIV in B cell non Hodgkin lymphoma in Kampala, Uganda
    (Uganda Infectious Agents and Cancer, 2010) Tumwine, Lynnette K.; Orem, Jackson; Kerchan, Patrick; Byarugaba, Wilson; Pileri, Stefano A.
    B cell non Hodgkin lymphomas account for the majority of lymphomas in Uganda. The commonest is endemic Burkitt lymphoma, followed by diffuse large-B-cell lymphoma (DLBCL). There has been an increase in incidence of malignant lymphoma since the onset of the HIV/AIDS pandemic. However, the possible linkages of HHV8 and EBV to the condition of impaired immunity present in AIDS are still not yet very clearly understood.
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    Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya
    (British journal of haematology, 2020) Peprah, Sally; Ogwang, Martin D.; Kerchan, Patrick; Reynolds, Steven J.; Tenge, Constance N.; Were, Pamela A.; Kuremu, Robert T.; Wekesa, Walter N.; Masalu, Nestory; Kawira, Esther; Kinyera, Tobias; Otim, Isaac; Legason, Ismail D.; Nabalende, Hadijah; Dhudha, Herry; Mumia, Mediatrix; Ayers, Leona W.; Biggar, Robert J.; Bhatia, Kishor; Goedert, James J.; Mbulaiteye, Sam M.
    Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case-control study in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in controls or eBL cases with or without malaria-infection in controls versus eBLcases were compared using Student’s t-test. Odds ratios (ORs) and two-sided 95% confidence intervals (95% CIs) were estimated using multiple logistic regression, controlling for age, sex, haemoglobin and white blood cell counts. Platelets were decreased with malaria infection in the controls [263 vs. 339 9 109 platelets/l, P < 0 0001; adjusted OR (aOR) = 3 42, 95% CI: 2 79–4 18] and eBL cases (314 vs. 367 9 109 platelets/ l, P-value = 0 002; aOR = 2 36, 95% CI: 1 49–3 73). Unexpectedly, platelets were elevated in eBL cases versus controls in overall analyses (mean: 353 vs. 307 9 109 platelets/l, P < 0 0001; aOR = 1 41; 95% CI: 1 12–1 77), and when restricted to malaria-positive (mean 314 vs. 263 9 109 platelets/ l, P < 0 0001; OR = 2 26; 95% CI: 1 56–3 27) or malaria-negative (mean 367 vs. 339 9 109 platelets/l, P < 0 001; OR = 1 46; 95% CI: 1 17–1 83) subjects. Platelets were decreased with malaria infection in controls and eBL cases but elevated with eBL.
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    Risk factors for Burkitt lymphoma in children in East Africa
    (Research Square, 2019) Peprah, Sally; Ogwang, Martin D.; Kerchan, Patrick; Reynolds, Steven J.; Tenge, Constance N.; Were, Pamela A.; Kuremu, Robert T.; Wekesa, Walter N.; Sumb, Peter O.; Masalu, Nestory; Kawira, Esther; Magatti, Josiah; Kinyera, Tobias; Otim, Isaac
    Endemic Burkitt lymphoma (eBL), a malignancy of immune B cells, is the most common childhood cancer in sub-Saharan Africa eBL is curable when it's identified early, but it's rapidly fatal without treatment Children in sub-Saharan Africa are over 50 times more likely to develop eBL than children living anywhere else in the world Unfortunately, few studies have examined the risk factors associated with eBL To address that gap, researchers conducted a study of eBL in children in three countries in East Africa They analyzed the relationship between eBL and infections, environmental, and genetic risk factors and focused their conclusions on results observed in at least two countries to minimize false-positives Risk of eBL was associated with low socio-economic status inpatient malaria treatment and living in areas targeted for malaria suppression In addition to exploring eBL risk factors, this study also demonstrates the potential to study cancer risk in East Africa and to detect, treat, or prevent eBL Learn more at emblem.cancer.gov Peprah et al. Risk factors for Burkitt lymphoma in East African children and minors. Int. J. Cancer. (2019)