Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
British journal of haematology
Abstract
Platelet counts are decreased in Plasmodium falciparum malaria, which is
aetiologically linked with endemic Burkitt lymphoma (eBL). However, the
pattern of platelet counts in eBL cases is unknown. We studied platelet
counts in 582 eBL cases and 2 248 controls enrolled in a case-control study
in Uganda, Tanzania and Kenya (2010–2016). Mean platelet counts in controls
or eBL cases with or without malaria-infection in controls versus
eBLcases were compared using Student’s t-test. Odds ratios (ORs) and
two-sided 95% confidence intervals (95% CIs) were estimated using multiple
logistic regression, controlling for age, sex, haemoglobin and white
blood cell counts. Platelets were decreased with malaria infection in the
controls [263 vs. 339 9 109 platelets/l, P < 0 0001; adjusted OR
(aOR) = 3 42, 95% CI: 2 79–4 18] and eBL cases (314 vs. 367 9 109 platelets/
l, P-value = 0 002; aOR = 2 36, 95% CI: 1 49–3 73). Unexpectedly, platelets
were elevated in eBL cases versus controls in overall analyses (mean:
353 vs. 307 9 109 platelets/l, P < 0 0001; aOR = 1 41; 95% CI: 1 12–1 77),
and when restricted to malaria-positive (mean 314 vs. 263 9 109 platelets/
l, P < 0 0001; OR = 2 26; 95% CI: 1 56–3 27) or malaria-negative (mean
367 vs. 339 9 109 platelets/l, P < 0 001; OR = 1 46; 95% CI: 1 17–1 83)
subjects. Platelets were decreased with malaria infection in controls and
eBL cases but elevated with eBL.
Description
Keywords
Burkitt lymphoma, Epidemiology, Epstein–Barr virus, Non- Hodgkin lymphoma, Plasmodium falciparum malaria, Platelet counts
Citation
Peprah, S., Ogwang, M. D., Kerchan, P., Reynolds, S. J., Tenge, C. N., Were, P. A., ... & Mbulaiteye, S. M. (2020). Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya. British journal of haematology, 190(5), 772-782. doi: 10.1111/bjh.16700