The rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda

Simple item page
dc.contributor.authorRedd, Andrew D.
dc.contributor.authorSsemwanga, Deogratius
dc.contributor.authorVandepitte, Judith
dc.contributor.authorWendel, Sarah K.
dc.contributor.authorNdembi, Nicaise
dc.contributor.authorBukenya, Justine
dc.contributor.authorNakubulwa, Susan
dc.contributor.authorGrosskurth, Heiner
dc.contributor.authorParry, Chris M.
dc.contributor.authorMartens, Craig
dc.contributor.authorBruno, Daniel
dc.contributor.authorPorcella, Stephen F.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorKaleebu, Pontiano
dc.date.accessioned2022-05-18T19:59:06Z
dc.date.available2022-05-18T19:59:06Z
dc.date.issued2008
dc.description.abstractTo determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers in Kampala, Uganda. Design—A retrospective analysis of individuals who participated in a clinical cohort study among high-risk female sex workers in Kampala, Uganda. Methods—Plasma samples from HIV-infected female sex workers (FSW) in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSW from the same cohort, and incidence rate ratios were compared. Results—The rate of superinfection in these women (7/85; 3.4/100py) was not significantly different from the rate of primary infection in the same population (3.7/100py; IRR=0.91, p=0.42). Seven women also entered the study dual infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (p=0.05), and trended to be older and more likely to be widowed (p=0.07). Conclusions—In this cohort of female sex workers, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar-workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.en_US
dc.identifier.citationMasiye, F., & Ssekubugu, R. (2008). Routine third party disclosure of HIV results to identifiable sexual partners in sub-Saharan Africa. Theoretical Medicine and Bioethics, 29(5), 341-348. doi:10.1097/QAD.0000000000000365.en_US
dc.identifier.other10.1097/QAD.0000000000000365.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3253
dc.language.isoenen_US
dc.publisherTheoretical Medicine and Bioethicsen_US
dc.subjectHIVen_US
dc.subjectPrimary HIV-1 infectionen_US
dc.subjectFemale sex workersen_US
dc.subjectUgandaen_US
dc.titleThe rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The rates of HIV-1 superinfection and primary HIV-1 infection are.pdf
Size:
226.09 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences