The rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
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Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
Theoretical Medicine and Bioethics
Abstract
To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers in Kampala, Uganda.
Design—A retrospective analysis of individuals who participated in a clinical cohort study among high-risk female sex workers in Kampala, Uganda.
Methods—Plasma samples from HIV-infected female sex workers (FSW) in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSW from the same cohort, and incidence rate ratios were compared.
Results—The rate of superinfection in these women (7/85; 3.4/100py) was not significantly different from the rate of primary infection in the same population (3.7/100py; IRR=0.91, p=0.42). Seven women also entered the study dual infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (p=0.05), and trended to be older and more likely to be widowed (p=0.07).
Conclusions—In this cohort of female sex workers, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar-workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.
Description
Keywords
HIV, Primary HIV-1 infection, Female sex workers, Uganda
Citation
Masiye, F., & Ssekubugu, R. (2008). Routine third party disclosure of HIV results to identifiable sexual partners in sub-Saharan Africa. Theoretical Medicine and Bioethics, 29(5), 341-348. doi:10.1097/QAD.0000000000000365.