An Observational Study in an Urban Ugandan Clinic comparing Virological Outcomes of Patients Switched from first-line Antiretroviral Regimens to Second-line Regimens containing Ritonavir-boosted Atazanavir or Ritonavir-boosted Lopinavir
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Infectious Diseases
Abstract
The World Health Organisation approved boosted atazanavir as a preferred second line protease inhibitor in 2010. This is as an alternative to the current boosted lopinavir. Atazanavir has a lower genetic barrier than lopinavir. We compared the virological outcomes of patients during the roll out of routine viral load monitoring, who had switched to boosted second- line regimens of either atazanavir or lopinavir.
Description
Keywords
Lopinavir, Second-line antiretroviral, Atazanavir, First-line failure
Citation
Laker, E. A. O., Nabaggala, M. S., Kaimal, A., Nalwanga, D., Castelnuovo, B., Musubire, A., ... & Ratanshi, R. P. (2019). An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir. BMC Infectious Diseases, 19(1), 1-7.https://doi.org/10.1186/s12879-019-3907-5