Determination of the G and P Types of Previously Nontypeable Rotavirus Strains from the African Rotavirus Network, 1996–2004: Identification of Unusual G Types

Simple item page
dc.contributor.authorEsona, Mathew Dioh
dc.contributor.authorSteele, Duncan
dc.contributor.authorNyangao, James
dc.contributor.authorSebunya, Theresia
dc.contributor.authorDewar, John
dc.contributor.authorGlass, Roger
dc.contributor.authorGentsch, Jon
dc.date.accessioned2023-04-01T20:03:02Z
dc.date.available2023-04-01T20:03:02Z
dc.date.issued2010
dc.description.abstractA total of 215 nontypeable rotavirus samples collected from children <5 years of age by members of the African Rotavirus Network were characterized using reverse-transcription polymerase chain reaction analysis and sequencing. The most predominant strain identified was P[8]G1 (46.9%). Genotypes P[8]G10, P[8]G8, P[6]G8, and P[7]G5 were also detected at frequencies varying from 0.5% to 2.3%. This study suggests that reassortment of unusual G types into a background of globally common genotype P[8] strains may be a major mechanism of generating rotavirus diversity. Nucleotide substitutions at the P[8], P[6], and G1 primer binding sites accounted for the failure to type these strains initially. Hence, these findings highlight the need for regular evaluation of rotavirus genotyping methods.en_US
dc.identifier.citationEsona, M. D., Steele, D., Kerin, T., Armah, G., Peenze, I., Geyer, A., ... & Gentsch, J. (2010). Determination of the G and P types of previously nontypeable rotavirus strains from the African Rotavirus Network, 1996–2004: identification of unusual G types. Journal of Infectious Diseases, 202(Supplement_1), S49-S54.https://doi.org/10.1086/653552en_US
dc.identifier.issn1537-6613
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8389
dc.language.isoenen_US
dc.publisherJournal of Infectious Diseasesen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectbinding sitesen_US
dc.subjectgenotypeen_US
dc.subjectgenotype determinationen_US
dc.titleDetermination of the G and P Types of Previously Nontypeable Rotavirus Strains from the African Rotavirus Network, 1996–2004: Identification of Unusual G Typesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Determination of the G and P Types of Previously Nontypeable Rotavirus Strains from the African Rotavirus Network, 1996–2004 Identification of Unusual G Types.pdf
Size:
272.12 KB
Format:
Adobe Portable Document Format
Description:
Determination of the G and P Types of Previously Nontypeable Rotavirus Strains from the African Rotavirus Network, 1996–2004: Identification of Unusual G Types
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences