Operationalization of COVID-19 Rapid Diagnosis Using Xpert® Xpress SARS CoV-2 Assay in Resource-Limited Settings: Early Implementation Lessons From Uganda

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dc.contributor.authorNsawotebba, Andrew
dc.contributor.authorIbanda, Ivan
dc.contributor.authorSsentalo Bagaya, Bernard
dc.contributor.authorNyombi, Abdunoor
dc.contributor.authorKagirita, Atek
dc.contributor.authorTugumisirize, Didas
dc.contributor.authorMujuni, Dennis
dc.contributor.authorMajwala, Robert Kaos
dc.contributor.authorOcen, Francis
dc.contributor.authorKabugo, Joel
dc.contributor.authorAdam, Isa
dc.contributor.authorWekiya, Enock
dc.contributor.authorMunduku, Benoni
dc.contributor.authorLinda, Lillian
dc.contributor.authorKalyesubula-Kibuuka, Simon
dc.contributor.authorOkiira, Christopher
dc.contributor.authorKigozi, Edgar
dc.contributor.authorOgwok, Patrick
dc.contributor.authorLutakoome Joloba, Moses
dc.contributor.authorNabadda, Susan
dc.contributor.authorSsengooba, Willy
dc.date.accessioned2022-06-06T20:33:09Z
dc.date.available2022-06-06T20:33:09Z
dc.date.issued2021
dc.description.abstractThe novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes COVID-19 disease is a global challenge. Several countries have adopted testing, isolation, and tracing strategy towards the control of the COVID-19 pandemic, but access to rapid and accurate testing is still a global challenge. The conventional PCR – based assay is the most commonly used test yet it has huge costs, infrastructural, and procurement logistical challenges. The Xpert® Xpress SARS-CoV-2 test is an automated in – vitro diagnostic test for the qualitative detection of nucleic acid from SARS-CoV-2 within a turnaround time of 60 minutes on the widely used GeneXpert Dx Instrument Systems. Here we document the best practices and challenges encountered with the operationalization of Xpert® Xpress SARS-CoV-2 testing in a resource-limited setting. Materials and Methods: The Xpert® Xpress SARS-CoV-2 implementation followed an operational work plan that included; Laboratory COVID-19 policy and planning, situational analysis of the Laboratory network, country Xpert® Xpress SARS-CoV-2 assay verification, and rollout at Mutukula Port Health Laboratory. The Laboratory strategy was based on a set of six objectives; conducting infrastructural modifications, building a strong COVID-19 testing capacity, developing robust Laboratory Quality and Information Management Systems, establishing a Bio-risk management and Bio-banking capacity.en_US
dc.identifier.citationNsawotebba, A., Ibanda, I., Ssewanyana, I., Bagaya, B. S., Nyombi, A., Kagirita, A., ... & Ssengooba, W. (2021). Operationalization of COVID-19 Rapid Diagnosis Using Xpert® Xpress SARS CoV-2 Assay in Resource-Limited Settings: Early Implementation Lessons From Uganda. https://doi.org/10.21203/rs.3.rs-154102/v1en_US
dc.identifier.urihttps://doi.org/10.21203/rs.3.rs-154102/v1
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3782
dc.language.isoenen_US
dc.publisherResearch Squareen_US
dc.subjectCOVID-19en_US
dc.subjectXpert® Xpress SARS CoV-2en_US
dc.subjectRapid diagnosisen_US
dc.subjectResource-Limited Settingsen_US
dc.subjectImplementationen_US
dc.titleOperationalization of COVID-19 Rapid Diagnosis Using Xpert® Xpress SARS CoV-2 Assay in Resource-Limited Settings: Early Implementation Lessons From Ugandaen_US
dc.typeArticleen_US
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