Histomorphometric and Biochemical Activities of Bioactive Component of Cyperus Esculentus Tubers Extract on Letrozole-induced Polycystic Ovarian Syndrome and Cholesterol Homeostasis in Female Sprague-Dawley rats

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dc.contributor.authorAdelakun, Sunday A.
dc.contributor.authorOjewale, Abdulfatai O.
dc.contributor.authorJeje, Sikirullai O.
dc.contributor.authorAdedotun, Oluwafemi A.
dc.date.accessioned2023-06-27T20:49:33Z
dc.date.available2023-06-27T20:49:33Z
dc.date.issued2022
dc.description.abstractPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal rats and twenty (20) PCOS rats (150–200 g, 8 weeks old) were randomly divided into four groups of ten (n = 10) rats each. Group A served as normal control group received 2 mL of normal saline, group B treated with 500 mg/kg body weight of CES, group C PCOS control group received 2 mL of normal saline, and group D PCOS rats post-treated with 500 mg/kg body weight of CES daily through gastric gavage for 30 days. Estrus cyclicity, body and ovaries weights, biochemical and histological parameters were measured. Observed irregular estrus cyclicity and multiple cysts in PCOS rats, increase glycemia, ovarian weight, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, malondialdehyde, luteinizing hormone (LH), testosterone, and decrease high-density lipoprotein cholesterol, estradiol, progesterone, catalase, reduced glutathione (GSH), and superoxide dismutase levels, compared with control. The intervention of CES ameliorated and restored the estrus cyclicity reproductive hormone, biochemical, and structural alterations. Moreover, CES significantly decreased cystic follicles, LH, and testosterone levels, but increased estradiol concentration. This plant may be beneficial in the management and treatment of PCOS-related reproductive and metabolic disorders.en_US
dc.identifier.citationAdelakun, S. A., Ojewale, A. O., Jeje, S. O., & Adedotun, O. A. (2022). Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats. Toxicology Research and Application, 6, 23978473221109475.https://doi.org/10.1177/23978473221109475en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9001
dc.language.isoenen_US
dc.publisherToxicology Research and Applicationen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectRaten_US
dc.subjectCyperus esculentusen_US
dc.subjectHormoneen_US
dc.titleHistomorphometric and Biochemical Activities of Bioactive Component of Cyperus Esculentus Tubers Extract on Letrozole-induced Polycystic Ovarian Syndrome and Cholesterol Homeostasis in Female Sprague-Dawley ratsen_US
dc.typeArticleen_US
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