Histomorphometric and Biochemical Activities of Bioactive Component of Cyperus Esculentus Tubers Extract on Letrozole-induced Polycystic Ovarian Syndrome and Cholesterol Homeostasis in Female Sprague-Dawley rats
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Toxicology Research and Application
Abstract
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, causes irregular menstrual
cycles, dyslipidemia, excessive body weight, oxidative stress, hyperandrogenism, and infertility. This study focused on the
impact of Cyperus esculentus (CES) on letrozole-induced PCOS in female Sprague-Dawley rats. Twenty (20) normal rats and
twenty (20) PCOS rats (150–200 g, 8 weeks old) were randomly divided into four groups of ten (n = 10) rats each. Group A
served as normal control group received 2 mL of normal saline, group B treated with 500 mg/kg body weight of CES, group
C PCOS control group received 2 mL of normal saline, and group D PCOS rats post-treated with 500 mg/kg body weight of
CES daily through gastric gavage for 30 days. Estrus cyclicity, body and ovaries weights, biochemical and histological
parameters were measured. Observed irregular estrus cyclicity and multiple cysts in PCOS rats, increase glycemia, ovarian
weight, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol,
malondialdehyde, luteinizing hormone (LH), testosterone, and decrease high-density lipoprotein cholesterol, estradiol,
progesterone, catalase, reduced glutathione (GSH), and superoxide dismutase levels, compared with control. The intervention of CES ameliorated and restored the estrus cyclicity reproductive hormone, biochemical, and structural alterations. Moreover, CES significantly decreased cystic follicles, LH, and testosterone levels, but increased estradiol
concentration. This plant may be beneficial in the management and treatment of PCOS-related reproductive and metabolic
disorders.
Description
Keywords
Polycystic ovary syndrome, Rat, Cyperus esculentus, Hormone
Citation
Adelakun, S. A., Ojewale, A. O., Jeje, S. O., & Adedotun, O. A. (2022). Histomorphometric and biochemical activities of bioactive component of Cyperus esculentus tubers extract on letrozole-induced polycystic ovarian syndrome and cholesterol homeostasis in female Sprague-Dawley rats. Toxicology Research and Application, 6, 23978473221109475.https://doi.org/10.1177/23978473221109475