Cervicovaginal Bacteriology and Antibiotic Sensitivity Patterns among Women with Premature Rupture of Membranes in Mulago Hospital, Kampala, Uganda: A Cross-Sectional Study

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dc.contributor.authorMusaba, Milton W.
dc.contributor.authorKagawa, Mike N.
dc.contributor.authorKiggundu, Charles
dc.contributor.authorKiondo, Paul
dc.contributor.authorWandabwa, Julius
dc.date.accessioned2023-03-30T16:56:49Z
dc.date.available2023-03-30T16:56:49Z
dc.date.issued2017
dc.description.abstractA 2013 Cochrane review concluded that the choice of antibiotics for prophylaxis in PROM is not clear. In Uganda, a combination of oral erythromycin and amoxicillin is the 1st line for prophylaxis against ascending infection. Our aim was to establish the current cervicovaginal bacteriology and antibiotic sensitivity patterns. Methods. Liquor was collected aseptically from the endocervical canal and pool in the posterior fornix of the vagina using a pipette. Aerobic cultures were performed on blood, chocolate, and MacConkey agar and incubated at 35โ€“37โˆ˜C for 24โ€“48 hrs. Enrichment media were utilized to culture for GBS and facultative anaerobes. Isolates were identified using colonial morphology, gram staining, and biochemical analysis. Sensitivity testing was performed via Kirby-Bauer disk diffusion and dilution method. Pearsonโ€™s chi-squared (๐œ’2) test and the paired t-test were applied, at a ๐‘ƒ value of 0.05. Results. Thirty percent of the cultures were positive and over 90% were aerobic microorganisms. Resistance to erythromycin, ampicillin, cotrimoxazole, and ceftriaxone was 44%, 95%, 96%, and 24%, respectively. Rupture of membranes (>12 hrs), late preterm, and term PROM were associated with more positive cultures. Conclusion. The spectrum of bacteria associated with PROM has not changed, but resistance to erythromycin and ampicillin has increased.en_US
dc.identifier.citationMusaba, M. W., Kagawa, M. N., Kiggundu, C., Kiondo, P., & Wandabwa, J. (2017). Cervicovaginal bacteriology and antibiotic sensitivity patterns among women with premature rupture of membranes in Mulago hospital, Kampala, Uganda: a cross-sectional study. Infectious diseases in obstetrics and gynecology, 2017. https://doi.org/10.1155/2017/9264571en_US
dc.identifier.urihttps://doi.org/10.1155/2017/9264571
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8343
dc.language.isoenen_US
dc.publisherInfectious diseases in obstetrics and gynecologyen_US
dc.subjectCervicovaginal Bacteriologyen_US
dc.subjectAntibiotic Sensitivity Patternsen_US
dc.subjectWomenen_US
dc.subjectPremature Ruptureen_US
dc.subjectMembranesen_US
dc.titleCervicovaginal Bacteriology and Antibiotic Sensitivity Patterns among Women with Premature Rupture of Membranes in Mulago Hospital, Kampala, Uganda: A Cross-Sectional Studyen_US
dc.typeArticleen_US
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