Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission

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dc.contributor.authorDamme, Lut Van
dc.contributor.authorGovinden, Roshini
dc.contributor.authorMirembe, Florence M.
dc.contributor.authorGuédou, Fernand
dc.contributor.authorSolomon, Suniti
dc.contributor.authorBecker, Marissa L.
dc.contributor.authorPradeep, B.S.
dc.contributor.authorKrishnan, A.K.
dc.contributor.authorAlary, Michel
dc.contributor.authorPande, Bina
dc.contributor.authorRamjee, Gita
dc.contributor.authorDeese, Jennifer
dc.contributor.authorCrucitti, Tania
dc.contributor.authorTaylor, Doug
dc.date.accessioned2022-01-21T20:59:29Z
dc.date.available2022-01-21T20:59:29Z
dc.date.issued2008
dc.description.abstractWomen make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed. Methods We performed a randomized, double-blind, placebo-controlled trial of cellulose sulfate, an HIV-entry inhibitor formulated as a vaginal gel, involving women at high risk for HIV infection at three African and two Indian sites. The primary end point was newly acquired infection with HIV type 1 or 2. The secondary end point was newly acquired gonococcal or chlamydial infection. The primary analysis was based on a log-rank test of no difference in the distribution of time to HIV infection, stratified according to site.en_US
dc.identifier.citationVan Damme, L., Govinden, R., Mirembe, F. M., Guédou, F., Solomon, S., Becker, M. L., ... & Taylor, D. (2008). Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. New England Journal of Medicine, 359(5), 463-472.en_US
dc.identifier.urihttps://www.nejm.org/doi/full/10.1056/NEJMoa0707957
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1406
dc.language.isoenen_US
dc.publisherNew England Journal of Medicineen_US
dc.subjectCellulose Sulfate Gelen_US
dc.subjectPreventionen_US
dc.subjectVaginal HIV Transmissionen_US
dc.titleLack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmissionen_US
dc.typeArticleen_US
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