Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission
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Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
New England Journal of Medicine
Abstract
Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed.
Methods We performed a randomized, double-blind, placebo-controlled trial of cellulose sulfate, an HIV-entry inhibitor formulated as a vaginal gel, involving women at high risk for HIV infection at three African and two Indian sites. The primary end point was newly acquired infection with HIV type 1 or 2. The secondary end point was newly acquired gonococcal or chlamydial infection. The primary analysis was based on a log-rank test of no difference in the distribution of time to HIV infection, stratified according to site.
Description
Keywords
Cellulose Sulfate Gel, Prevention, Vaginal HIV Transmission
Citation
Van Damme, L., Govinden, R., Mirembe, F. M., Guédou, F., Solomon, S., Becker, M. L., ... & Taylor, D. (2008). Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. New England Journal of Medicine, 359(5), 463-472.