Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Critical care research and practice
Abstract
In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. We sought to identify clinical characteristics and survival outcomes among HIV patients in a low-income country ICU. Materials and Methods. A retrospective cohort study of HIV infected patients admitted to a university teaching hospital ICU in Uganda. Medical records were reviewed. Primary outcome was survival to hospital discharge. Statistical significance was predetermined in reference to . Results. There were 101 HIV patients. Average length of ICU stay was 4 days and ICU mortality was 57%. Mortality in non-HIV patients was 28%. Commonest admission diagnoses were Acute Respiratory Distress Syndrome (ARDS) (58.4%), multiorgan failure (20.8%), and sepsis (20.8%). The mean Acute Physiologic and Chronic Health Evaluation (APACHE II) score was 24. At multivariate analysis, APACHE II (OR 1.24 (95% CI: 1.1–1.4, )), mechanical ventilation (OR 1.14 (95% CI: 0.09–0.76, )), and ARDS (OR 4.5 (95% CI: 1.07–16.7, )) had a statistically significant association with mortality. Conclusion. ICU mortality of HIV patients is higher than in higher income settings and the non-HIV population. ARDS, APACHE II, and need for mechanical ventilation are significantly associated with mortality.
Description
Keywords
Intensive Care Unit, HIV Patients, Clinical Characteristics
Citation
Kwizera, A., Nabukenya, M., Peter, A., Semogerere, L., Ayebale, E., Katabira, C., ... & Nakibuuka, J. (2016). Clinical characteristics and short-term outcomes of HIV patients admitted to an African intensive care unit. Critical care research and practice, 2016.https://doi.org/10.1155/2016/2610873