Vaccine Associated Paralytic Poliomyelitis Cases From Children Presenting With Acute Flaccid Paralysis in Uganda

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dc.contributor.authorNanteza, Mary B.
dc.contributor.authorKisakye, Annet
dc.contributor.authorOta, Martin O.
dc.contributor.authorGumede, Nicksy
dc.contributor.authorBwogi, Josephine
dc.date.accessioned2022-01-20T18:33:17Z
dc.date.available2022-01-20T18:33:17Z
dc.date.issued2015
dc.description.abstractPoliomyelitis is caused by Poliovirus 1, 2, and 3 which belong to the family Picornaviridae and the genus Enterovirus. Paralytic polio usually affects one lower limb and presents with hypotonia, reduced reflexes, wasting of muscles but with no loss of sensorium. Plans to eradicate poliomyelitis are intensively on-going and these are being achieved by the use of both oral polio vaccine (OPV) as well as the inactivated polio vaccine (IPV). The viral strains in OPV (Sabins) are unstable (Agol, 2006) for example Sabin poliovirus 1 harbors an attenuating mutation of A480G in the 50UTR whereas that of Sabin Poliovirus 2 and 3 are at the G481A and C472U sites respectively [Kew et al., 2004; Kew, 2009]. The mutations at these specific sites are not infrequent. They are associated rarely with increased neurovirulence and only infrequently cause AFP. This underrates their importance.en_US
dc.identifier.citationNanteza, M. B., Kisakye, A., Ota, M. O., Gumede, N., Bwogi, J., & Expanded Program on Immunization Laboratory Team‐Uganda Virus Research Institute (EPI LAB‐UVRI). (2015). Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda. Journal of medical virology, 87(12), 2163-2167. DOI 10.1002/jmv.24285en_US
dc.identifier.other10.1002/jmv.24285
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1350
dc.language.isoenen_US
dc.publisherJournal of medical virologyen_US
dc.subjectOPVen_US
dc.subjectAdverse eventen_US
dc.subjectUgandaen_US
dc.titleVaccine Associated Paralytic Poliomyelitis Cases From Children Presenting With Acute Flaccid Paralysis in Ugandaen_US
dc.typeArticleen_US
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