Vaccine Associated Paralytic Poliomyelitis Cases From Children Presenting With Acute Flaccid Paralysis in Uganda
Loading...
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of medical virology
Abstract
Poliomyelitis is caused by Poliovirus 1, 2, and 3 which belong to the family Picornaviridae and the genus Enterovirus. Paralytic polio usually affects one lower limb and presents with hypotonia, reduced reflexes, wasting of muscles but with no loss of sensorium. Plans to eradicate poliomyelitis are intensively on-going and these are being achieved by the use of both oral polio vaccine (OPV) as well as the inactivated polio vaccine (IPV). The viral strains in OPV (Sabins) are unstable (Agol, 2006) for example Sabin poliovirus 1 harbors an attenuating mutation of A480G in the 50UTR whereas that of Sabin Poliovirus 2 and 3 are at the G481A and C472U sites respectively [Kew et al., 2004; Kew, 2009]. The mutations at these specific sites are not infrequent. They are associated rarely with increased neurovirulence and only infrequently cause AFP. This underrates their importance.
Description
Keywords
OPV, Adverse event, Uganda
Citation
Nanteza, M. B., Kisakye, A., Ota, M. O., Gumede, N., Bwogi, J., & Expanded Program on Immunization Laboratory Team‐Uganda Virus Research Institute (EPI LAB‐UVRI). (2015). Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda. Journal of medical virology, 87(12), 2163-2167. DOI 10.1002/jmv.24285