Human Herpesvirus Type 8 Variants Circulating In Europe, Africa And North America In Classic, Endemic And Epidemic Kaposi's Sarcoma Lesions During Pre-AIDS and AIDS Era

Simple item page
dc.contributor.authorTornesello, Maria Lina
dc.contributor.authorBiryahwaho, Benon
dc.contributor.authorDowning, Robert
dc.contributor.authorHatzakis, Angelo
dc.contributor.authorAlessi, Elvio
dc.contributor.authorCusini, Marco
dc.contributor.authorRuocco, Vincenzo
dc.contributor.authorMbidde, Edward Katongole
dc.contributor.authorLoquercio, Giovanna
dc.contributor.authorBuonaguro, Luigi
dc.contributor.authorBuonaguro, Franco M.
dc.date.accessioned2022-01-24T20:27:25Z
dc.date.available2022-01-24T20:27:25Z
dc.date.issued2010
dc.description.abstractHuman herpesvirus-8 (HHV-8) variants have been found heterogeneously distributed among human populations living in diverse geographic regions, but their differential pathogenicity in Kaposi's sarcoma development remains controversial. In the present study, HHV-8 variant distribution has been analyzed in classic, iatrogenic, endemic as well as epidemic Kaposi's sarcoma (KS) during pre-AIDS and AIDS period (1971–2008) in countries with different KS incidence rate. DNA samples from cutaneous KS lesions of 68 patients living in Africa (n = 23, Cameroon, Kenya and Uganda), Europe (n = 34, Greece and Italy) and North America (n = 11) have been subjected to PCR amplification of HHV-8 ORF 26, T0.7, K1 and K14.1/15, followed by direct nucleotide sequencing and phylogenetic analysis. Among the 23 African samples, the majority of HHV-8 ORF 26 variants clustered with the subtype R (n = 12) and B (n = 5). Conversely, the viral sequences obtained from 45 European and North European tumors belonged mainly to subtype A/C (n = 36). In general, HHV-8 and K1 variant clustering paralleled that of ORF 26 and T0.7. Genotyping of the K14.1/15 loci revealed a large predominance of P subtype in all tumors. In conclusion, comparison of the HHV-8 sequences from classic or endemic versus AIDS-associated KS showed a strong linkage of the HHV-8 variants with specific populations, which has not changed during AIDS epidemic.en_US
dc.identifier.citationTornesello, M. L., Biryahwaho, B., Downing, R., Hatzakis, A., Alessi, E., Cusini, M., ... & Buonaguro, F. M. (2010). Human herpesvirus type 8 variants circulating in Europe, Africa and North America in classic, endemic and epidemic Kaposi's sarcoma lesions during pre-AIDS and AIDS era. Virology, 398(2), 280-289.https://doi.org/10.1016/j.virol.2009.12.005en_US
dc.identifier.issn0042-6822
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1529
dc.language.isoenen_US
dc.publisherVirologyen_US
dc.subjectKaposi's sarcoma; Human herpes virus type 8; (HHV-8)HHV-8 ORF 26; HHV-8 ORF K1en_US
dc.titleHuman Herpesvirus Type 8 Variants Circulating In Europe, Africa And North America In Classic, Endemic And Epidemic Kaposi's Sarcoma Lesions During Pre-AIDS and AIDS Eraen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Human Herpesvirus Type 8 Variants Circulating In Europe, Africa And North America In Classic, Endemic And Epidemic Kaposi's Sarcoma Lesions During Pre-AIDS and AIDS Era.pdf
Size:
937.55 KB
Format:
Adobe Portable Document Format
Description:
Human Herpesvirus Type 8 Variants Circulating In Europe, Africa And North America In Classic, Endemic And Epidemic Kaposi's Sarcoma Lesions During Pre-AIDS and AIDS Era
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences