Nanotechnological Solutions For Controlling Transmission And Emergence Of Antimicrobial-Resistant Bacteria, Future Prospects, And Challenges: A Systematic Review

Simple item page
dc.contributor.authorSsekatawa, Kenneth
dc.contributor.authorByarugaba, Dennis K.
dc.contributor.authorKato, Charles D.
dc.contributor.authorEjobi, Francis
dc.contributor.authorTweyongyere, Robert
dc.contributor.authorLubwama, Michael
dc.contributor.authorKirabira, John Baptist
dc.contributor.authorWampande, Eddie M.
dc.date.accessioned2022-01-19T21:15:15Z
dc.date.available2022-01-19T21:15:15Z
dc.date.issued2020
dc.description.abstractGlobally, a high prevalence of multi-drug-resistant (MDR) bacteria, mostly methicillin-resistant Staphylococcus aureus and carbapenem-resistant Enterobacteriaceae, has been reported. Infections caused by such bacteria are expensive and hard to treat due to reduced efficient treatment alternatives. Centered on the current rate of antibiotics production and approvals, it is anticipated that by 2050 up to 10 million people could die annually due to MDR pathogens. To this effect, alternative strategies such as the use of nanotechnology to formulate nanobactericidal agents are being explored. This systematic review addresses the recent approaches, future prospects, and challenges of nanotechnological solutions for controlling transmission and emergence of antibiotic resistance. A comprehensive literature search of PubMed and BioMed Central databases from June 2018 to January 2019 was performed. The search keywords used were “use of nanotechnology to control antibiotic resistance” to extract articles published only in English encompassing all research papers regardless of the year of publication. PubMed and BioMed Central databases literature exploration generated 166 articles of which 49 full-text research articles met the inclusion guidelines. Of the included articles, 44.9%, 30.6%, and 24.5% reported the use of inorganic, hybrid, and organic nanoparticles, respectively, as bactericidal agents or carriers/enhancers of bactericidal agents. Owing to the ever-increasing prevalence of antimicrobial resistance to old and newly synthesized drugs, alternative approaches such as nanotechnology are highly commendable. This is supported by in vitro, ex vivo, and in vivo studies assessed in this review as they reported high bactericide efficacies of organic, inorganic, and hybrid nanoparticles.en_US
dc.identifier.citationSsekatawa, K., Byarugaba, D. K., Kato, C. D., Ejobi, F., Tweyongyere, R., Lubwama, M., ... & Wampande, E. M. (2020). Nanotechnological solutions for controlling transmission and emergence of antimicrobial-resistant bacteria, future prospects, and challenges: a systematic review. Journal of Nanoparticle Research, 22, 1-30. https://doi.org/10.1007/s11051-020-04817-7en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1326
dc.language.isoenen_US
dc.publisherJournal of Nanoparticle Researchen_US
dc.subjectMultidrug resistance . Inorganic nanoparticles . Organic nanoparticles . Nanohybrid . Nanocarriers . Cytotoxicity . Nanomedicineen_US
dc.titleNanotechnological Solutions For Controlling Transmission And Emergence Of Antimicrobial-Resistant Bacteria, Future Prospects, And Challenges: A Systematic Reviewen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nanotechnological Solutions For Controlling Transmission.pdf
Size:
896.85 KB
Format:
Adobe Portable Document Format
Description:
Nanotechnological Solutions For Controlling Transmission And Emergence Of Antimicrobial-Resistant Bacteria, Future Prospects, And Challenges: A Systematic Review
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Engineering and Technology