Iron acquisition from transferrin and Iactoferrin by Pseudornonas aeruginosa pyoverdin
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Date
1997
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Microbiology
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen which is frequently found in clinical specimens from burns, surface wounds, urinary tract, ear and eye infections, and is commonly isolated from the lungs of patients with cystic fibrosis (CF)(Doggett et al., 1966; Reynolds et al., 1976). In response to iron deprivation P. aeruginosa produces two unrelated siderophores, pyoverdin and pyochelin, as well as membrane receptors for binding the corresponding iron-siderophore complexes. Both of these siderophores promoted the growth of P. aeruginosa when added to medium with iron-transferrin or human sera as the iron sources (Ankenbauer et al., 1985). Because of the higher iron-pyoverdin binding constant (lo3,)(Demange et al., 1990), in comparison to that of iron-pyochelin (lo5)(Cox & Graham, 1979), pyoverdin was considered to be more effective. It has been reported that a pyochelin-deficient mutant (Pvd+ Pch-) strain grew as well as the parent strain whereas a pyoverdin-deficient mutant (Pvd-Pch+) exhi-Abbreviations: CF, cystic fibrosis; ICP, inductively coupled plasma. bited severely retarded growth (Ankenbauer et al., 1985).
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Xiao, R., & Kisaalita, W. S. (1997). Iron acquisition from transferrin and iactoferrin by Pseudornonas aeruginosa pyoverdin. Microbiology, 143, 2497-2507.