CD81 T Cells Provide an Immunologic Signature of Tuberculosis in Young Children

Simple item page
dc.contributor.authorLancioni, Christina
dc.contributor.authorNyendak, Mellisa
dc.contributor.authorSarah Zalwango, Sarah Kiguli
dc.contributor.authorMori, Tomi
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorBalyejusa, Stephen
dc.contributor.authorNull, Megan
dc.contributor.authorBaseke, Joy
dc.contributor.authorMulindwa, Deo
dc.contributor.authorByrd, Laura
dc.contributor.authorSwarbrick, Gwendolyn
dc.contributor.authorScott, Christine
dc.contributor.authorJohnson, Denise F.
dc.contributor.authorMalone, LaShaunda
dc.contributor.authorMudido-Musoke, Philipa
dc.contributor.authorBoom, Henry
dc.contributor.authorLewinsohn, David M.
dc.contributor.authorLewinsohn, Deborah A.
dc.date.accessioned2021-12-09T10:52:26Z
dc.date.available2021-12-09T10:52:26Z
dc.date.issued2011
dc.description.abstractMycobacterium tuberculosis (Mtb), the etiology of tuberculosis (TB), causes over 9 million cases of disease and 1.7 million deaths annually (1). The only available vaccine to prevent TB, bacillus Calmette-Gue´ rin, offers little protection against the most common disease manifestations (2) and efforts to develop an improved vaccine are hampered by poor understanding of immunologic events that occur after Mtb exposure. Scientific studies of immunologic responses to initial Mtb infection are difficult because most individuals living in TB-endemic settings have experienced multiple Mtb exposures. Young children, however, suffer disproportionately after exposure to Mtb, because they are at substantial risk for developing TB after primary infection (3–5). Therefore, young children with TB offer a valuable window into the human immune response to primary Mtb infection.en_US
dc.identifier.citationLancioni, C., Nyendak, M., Kiguli, S., Zalwango, S., Mori, T., Mayanja-Kizza, H., ... & Lewinsohn, DA (2012). CD8 + T cells provide an immunologic signature of tuberculosis in young children. American journal of respiratory and critical care medicine , 185 (2), 206-212. DOI: 10.1164/rccm.201107-1355OCen_US
dc.identifier.other10.1164/rccm.201107-1355OC
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/219
dc.language.isoenen_US
dc.publisherAmerican Thoracic Societyen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectInfanten_US
dc.subjectChilden_US
dc.subjectCD8-positive T lymphocytesen_US
dc.subjectEnzyme-linked immunosorbent spoten_US
dc.titleCD81 T Cells Provide an Immunologic Signature of Tuberculosis in Young Childrenen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CD81 T Cells Provide an Immunologic Signature.pdf
Size:
168.26 KB
Format:
Adobe Portable Document Format
Description:
PDF
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences