CD81 T Cells Provide an Immunologic Signature of Tuberculosis in Young Children

Mycobacterium tuberculosis (Mtb), the etiology of tuberculosis (TB), causes over 9 million cases of disease and 1.7 million deaths annually (1). The only available vaccine to prevent TB, bacillus Calmette-Gue´ rin, offers little protection against the most common disease manifestations (2) and efforts to develop an improved vaccine are hampered by poor understanding of immunologic events that occur after Mtb exposure. Scientific studies of immunologic responses to initial Mtb infection are difficult because most individuals living in TB-endemic settings have experienced multiple Mtb exposures. Young children, however, suffer disproportionately after exposure to Mtb, because they are at substantial risk for developing TB after primary infection (3–5). Therefore, young children with TB offer a valuable window into the human immune response to primary Mtb infection.

Keywords

Mycobacterium tuberculosis, Infant, Child, CD8-positive T lymphocytes, Enzyme-linked immunosorbent spot

Citation

Lancioni, C., Nyendak, M., Kiguli, S., Zalwango, S., Mori, T., Mayanja-Kizza, H., ... & Lewinsohn, DA (2012). CD8 + T cells provide an immunologic signature of tuberculosis in young children. American journal of respiratory and critical care medicine , 185 (2), 206-212. DOI: 10.1164/rccm.201107-1355OC

URI

https://nru.uncst.go.ug/xmlui/handle/123456789/219

Collections

Medical and Health Sciences

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