Prevalence of brucellosis among patients attending Wau Hospital, South Sudan
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
PloS one
Abstract
Brucellosis is a zoonotic disease of public health importance; its prevalence varies globally.
In low-income countries, brucellosis is an endemic and neglected disease affecting both animals
and humans. This study was intended to establish brucellosis sero-prevalence among
patients attending Wau hospital, South Sudan. Across sectional study, was done among
randomly selected patients attending Wau hospital. Data was collected using questionnaires
and laboratory investigations. Rose Bengal plate Test (RBPT), Serum agglutination
test (SAT) and Competitive Enzyme Linked Immuno Sorbent Assay (c-ELISA) was used in
the analysis of blood samples serially starting with RBPT which is more sensitive and least
specific then SAT. c-ELISA test which is most specific and less sensitive compared to RBPT
and SAT was then used to confirm presence of Brucella antibodies in the samples. A total of
416 participants out of 1664 were enrolled to this study. The majority of participants were
between 7-to-76 years of age with mean age of 30.72 (SD+/- 12.83). The sero-positivity of
patient's blood samples for brucellosis using c-ELISA was 23.3% (97/416) among patients
presenting to Wau hospital. Socio-demographic characteristics, occupation, clinical signs of
disease and types of animals reared by animal owners showed no significant correlation
with occurrence of sero-positivity among patient's blood samples for brucellosis. While ethnicity
(Nilotic), knowledge of zoonotic disease, and consumption of animal urine were statistically
significant (p<0.05). The study found a high prevalence of brucellosis among febrile
patients attending Wau hospital general outpatient clinic. There is need for co-ordination
and collaboration between veterinary and health sectors of government to help prevent and
control brucellosis in the region.
Description
Keywords
Brucellosis, Patients, Wau Hospital, South Sudan
Citation
Madut NA, Nasinyama GW, Muma JB, Sube KLL, Ocan M, Muwonge A, et al. (2018) Prevalence of brucellosis among patients attending Wau Hospital, South Sudan. PLoS ONE 13(6): e0199315. https://doi.org/10.1371/journal. pone.0199315