Solid-State Deuterium NMR Studies Reveal μs-ns Motions in the HIV-1 TAR RNA Recognition Site

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dc.contributor.authorOlsen, Greg L.
dc.contributor.authorEchodu, Dorothy C.
dc.contributor.authorShajani, Zahra
dc.contributor.authorBardaro Jr., Michael F.
dc.contributor.authorVarani, Gabriele
dc.contributor.authorDrobny, Gary P.
dc.date.accessioned2022-11-20T10:23:48Z
dc.date.available2022-11-20T10:23:48Z
dc.date.issued2008
dc.description.abstractSolution and solid-state NMR measurements were used together to examine motion in three sites in the HIV-1 TAR RNA. We wished to investigate the dynamics facilitating the conformational rearrangements the TAR RNA must undergo for tat binding, and in particular to characterize the full range of motional timescales accessible to this RNA. Our results demonstrate that the dynamics in TAR involving residues essential to tat binding include not only the faster motions detected by solution relaxation measurements, but also a significant component in the μs-ns timescale.en_US
dc.identifier.citationOlsen, GL, Echodu, DC, Shajani, Z., Bardaro, MF, Varani, G., & Drobny, GP (2008). Solid-state deuterium NMR studies reveal μs-ns motions in the HIV-1 transactivation response RNA recognition site. Journal of the American Chemical Society, doi:10.1021/ja0778803.en_US
dc.identifier.other10.1021/ja0778803.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5357
dc.language.isoenen_US
dc.publisherJournal of the American Chemical Societyen_US
dc.subjectSolid-State Deuterium NMR Studiesen_US
dc.subjectμs-ns Motionsen_US
dc.subjectHIV-1 TAR RNAen_US
dc.subjectRecognition Siteen_US
dc.titleSolid-State Deuterium NMR Studies Reveal μs-ns Motions in the HIV-1 TAR RNA Recognition Siteen_US
dc.typeArticleen_US
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