Characterization of micropatterned nanofibrous scaffolds for neural network activity readout for high-throughput screening

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dc.contributor.authorWang, Lina
dc.contributor.authorKisaalita, William S.
dc.date.accessioned2025-04-15T15:38:20Z
dc.date.available2025-04-15T15:38:20Z
dc.date.issued2010
dc.description.abstractMicropatterns were fabricated in nanofibrous poly‐L‐lactic acid (PLLA) films by laser micromachining and the resulting scaffolds were characterized with respect to architecture, thermal, mechanical, and mass transport properties. Also, human neural stem cells were successfully cultured in these micropatterned nanofibrous scaffolds (MNFSs). The scaffolds were incorporated in high‐density well plates (e.g., 96‐well plates), creating a platform for high‐throughput screening of drugs with physiologically more relevant networked neural cultures. Through mathematical modeling of the transport of model stimulants, the feasibility of stimulating neural networks cultured in MNFSs was demonstrated. More work is needed to establish biological network activity–MNFS architecture relationships. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
dc.identifier.citationWang, L., & Kisaalita, W. S. (2010). Characterization of micropatterned nanofibrous scaffolds for neural network activity readout for high‐throughput screening. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 94(1), 238-249.DOI: 10.1002/jbm.b.31646
dc.identifier.issnDOI: 10.1002/jbm.b.31646
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10727
dc.language.isoen
dc.publisherApplied Biomaterials
dc.titleCharacterization of micropatterned nanofibrous scaffolds for neural network activity readout for high-throughput screening
dc.typeArticle
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