Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy

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dc.contributor.authorStöhr, Wolfgang
dc.contributor.authorFidler, Sarah
dc.contributor.authorMcClure, Myra
dc.contributor.authorWeber, Jonathan
dc.contributor.authorCooper, David
dc.contributor.authorRamjee, Gita
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorTambussi, Giuseppe
dc.contributor.authorSchechter, Mauro
dc.contributor.authorBabiker, Abdel
dc.contributor.authorPhillips, Rodney E.
dc.contributor.authorPorter, Kholoud
dc.contributor.authorFrater, John
dc.date.accessioned2022-01-05T12:43:56Z
dc.date.available2022-01-05T12:43:56Z
dc.date.issued2013
dc.description.abstractA minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored. Design: And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used. 165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks. In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), pen_US
dc.identifier.citationStöhr W, Fidler S, McClure M, Weber J, Cooper D, et al. (2013) Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. PLoS ONE 8(10): e78287. doi:10.1371/journal.pone.0078287en_US
dc.identifier.uri10.1371/journal.pone.0078287
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1087
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.relation.ispartofseriesPLoS ONE;8(10)
dc.subjectHIV-1 Viral Suppressionen_US
dc.subjectAntiretroviral Therapyen_US
dc.subjectPrimary Infectionen_US
dc.titleDuration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapyen_US
dc.typeArticleen_US
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