Serum Prostate Specific Antigen Changes in Cynomolgus Monkeys (Macaca fascicularis) on a High Sugar High Fat Diet

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dc.contributor.authorMubiru, James N.
dc.contributor.authorGarcia-Forey, Magdalena
dc.contributor.authorCavazos, Nicole
dc.contributor.authorHemmat, Peggah
dc.contributor.authorDick, Edward J.
dc.contributor.authorOwston, Michael A.
dc.contributor.authorBauer, Cassondra A.
dc.contributor.authorShade, Robert E.
dc.contributor.authorRogers, Jeffrey
dc.date.accessioned2023-06-23T18:21:30Z
dc.date.available2023-06-23T18:21:30Z
dc.date.issued2012
dc.description.abstractAn inverse relationship between serum prostate specific antigen (PSA) levels and body mass index (BMI) has been reported in men but not in any animal model. METHODS. Serum PSA in a colony of cynomolgus monkeys was assayed and correlated to body weight, prostate weight, and age. In addition, 15 animals were selected and fed a high sugar high fat (HSHF) diet for 49 weeks to increase their BMI and correlate it to PSA RESULTS. Serum PSA levels were positively correlated to prostate weight (r ¼ 0.515, P ¼ 0.025) and age (r ¼ 0.548, P ¼ 0.00072) but was not significantly correlated to body weight (r ¼ 0.032, P ¼ 0.419). For the animals on the HSHF diet, body weight, lean mass, fat mass, and BMI were significantly higher at 49 weeks than at baseline (P < 0.01). PSA was not significantly correlated to body weight and insulin at both baseline and 49 weeks. PSA was negatively correlated to BMI and insulin resistance (HOMA-IR) at 49 weeks but not at baseline. In addition, we observed hepatic steatosis and increases in serum liver enzymes. CONCLUSIONS. Increases in BMI in cynomolgus monkeys as a result of consuming a HSHF diet resulted in PSA changes similar to those in humans with increased BMI. Cynomolgus monkeys are a useful model for investigating the relationship between obesity, diabetes, and PSA changes resulting from prostate gland pathology.en_US
dc.identifier.citationMubiru, J. N., Garcia‐Forey, M., Cavazos, N., Hemmat, P., Dick Jr, E. J., Owston, M. A., ... & Rogers, J. (2012). Serum prostate specific antigen changes in cynomolgus monkeys (Macaca fascicularis) on a high sugar high fat diet. The Prostate, 72(5), 469-475. DOI 10.1002/pros.21448en_US
dc.identifier.uri10.1002/pros.21448
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8984
dc.language.isoenen_US
dc.publisherThe Prostateen_US
dc.subjectDiabetesen_US
dc.subjectInsulin resistanceen_US
dc.subjectBMIen_US
dc.titleSerum Prostate Specific Antigen Changes in Cynomolgus Monkeys (Macaca fascicularis) on a High Sugar High Fat Dieten_US
dc.typeArticleen_US
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