Serum Prostate Specific Antigen Changes in Cynomolgus Monkeys (Macaca fascicularis) on a High Sugar High Fat Diet
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
The Prostate
Abstract
An inverse relationship between serum prostate specific antigen (PSA)
levels and body mass index (BMI) has been reported in men but not in any animal model.
METHODS. Serum PSA in a colony of cynomolgus monkeys was assayed and correlated to
body weight, prostate weight, and age. In addition, 15 animals were selected and fed a high
sugar high fat (HSHF) diet for 49 weeks to increase their BMI and correlate it to PSA
RESULTS. Serum PSA levels were positively correlated to prostate weight (r ¼ 0.515,
P ¼ 0.025) and age (r ¼ 0.548, P ¼ 0.00072) but was not significantly correlated to body
weight (r ¼ 0.032, P ¼ 0.419). For the animals on the HSHF diet, body weight, lean mass,
fat mass, and BMI were significantly higher at 49 weeks than at baseline (P < 0.01). PSA was
not significantly correlated to body weight and insulin at both baseline and 49 weeks. PSA
was negatively correlated to BMI and insulin resistance (HOMA-IR) at 49 weeks but not at
baseline. In addition, we observed hepatic steatosis and increases in serum liver enzymes.
CONCLUSIONS. Increases in BMI in cynomolgus monkeys as a result of consuming
a HSHF diet resulted in PSA changes similar to those in humans with increased BMI.
Cynomolgus monkeys are a useful model for investigating the relationship between obesity,
diabetes, and PSA changes resulting from prostate gland pathology.
Description
Keywords
Diabetes, Insulin resistance, BMI
Citation
Mubiru, J. N., Garcia‐Forey, M., Cavazos, N., Hemmat, P., Dick Jr, E. J., Owston, M. A., ... & Rogers, J. (2012). Serum prostate specific antigen changes in cynomolgus monkeys (Macaca fascicularis) on a high sugar high fat diet. The Prostate, 72(5), 469-475. DOI 10.1002/pros.21448