Total Lymphocyte Count: not a surrogate marker for risk of death in HIV infected Ugandan children

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dc.contributor.authorMusoke, Philippa M.
dc.contributor.authorYoung, Alicia M.
dc.contributor.authorOwor, Maxensia A.
dc.contributor.authorLubega, Irene R.
dc.contributor.authorBrown, Elizabeth R.
dc.contributor.authorMmiro, Francis A.
dc.contributor.authorMofenson, Lynne M.
dc.contributor.authorJackson, J. Brooks
dc.contributor.authorGlenn Fowler, Mary
dc.contributor.authorGuay, Laura A.
dc.date.accessioned2022-03-08T12:29:44Z
dc.date.available2022-03-08T12:29:44Z
dc.date.issued2008
dc.description.abstractTo determine the utility of Total Lymphocyte Count (TLC) in predicting the 12 month mortality in HIV infected Ugandan children; to correlate TLC and CD4 cell %. Design—This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV infected children in the HIVNET 012 trial. Methods—TLC and CD4 cell % measurements were obtained at birth, 14 weeks and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months. Results—Median TLC/ul (CD4 cell %) were 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19 %) at 36 months, 4100 (18%) at 48 months and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34–37% at birth and declined to 13– 15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01). Conclusion—The TLC did not predict a risk of progression to death within 12 months and therefore TLC alone may not be a useful surrogate marker for determining those children in greatest need for antiretroviral therapy in HIV infected Ugandan children.en_US
dc.identifier.citationMusoke, P. M., Young, A. M., Owor, M. A., Lubega, I. R., Brown, E. R., Mmiro, F. A., ... & Guay, L. A. (2008). Total Lymphocyte Count: Not a surrogate marker for risk of death in HIV infected Ugandan children. Journal of acquired immune deficiency syndromes (1999), 49(2), 171. doi:10.1097/QAI.0b013e318183a92a.en_US
dc.identifier.other10.1097/QAI.0b013e318183a92a.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2564
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectTotal Lymphocyte Counten_US
dc.subjectHIVen_US
dc.subjectAfricaen_US
dc.subjectChildrenen_US
dc.titleTotal Lymphocyte Count: not a surrogate marker for risk of death in HIV infected Ugandan childrenen_US
dc.typeArticleen_US
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