Total Lymphocyte Count: not a surrogate marker for risk of death in HIV infected Ugandan children
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Date
2008
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of acquired immune deficiency syndromes
Abstract
To determine the utility of Total Lymphocyte Count (TLC) in predicting the 12 month
mortality in HIV infected Ugandan children; to correlate TLC and CD4 cell %.
Design—This is a retrospective data analysis of clinical and laboratory data collected prospectively
on 128 HIV infected children in the HIVNET 012 trial.
Methods—TLC and CD4 cell % measurements were obtained at birth, 14 weeks and 12, 24, 36,
48, and 60 months of age and assessed with respect to risk of death within 12 months.
Results—Median TLC/ul (CD4 cell %) were 4150 (41%) at birth, 4900 (24%) at 12 months, 4300
(19%) at 24 months, 4150 (19 %) at 36 months, 4100 (18%) at 48 months and 3800 (20%) at 60
months. The highest risk of mortality within 12 months was 34–37% at birth and declined to 13–
15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC
was extremely low overall (r = 0.01).
Conclusion—The TLC did not predict a risk of progression to death within 12 months and therefore
TLC alone may not be a useful surrogate marker for determining those children in greatest need for
antiretroviral therapy in HIV infected Ugandan children.
Description
Keywords
Total Lymphocyte Count, HIV, Africa, Children
Citation
Musoke, P. M., Young, A. M., Owor, M. A., Lubega, I. R., Brown, E. R., Mmiro, F. A., ... & Guay, L. A. (2008). Total Lymphocyte Count: Not a surrogate marker for risk of death in HIV infected Ugandan children. Journal of acquired immune deficiency syndromes (1999), 49(2), 171. doi:10.1097/QAI.0b013e318183a92a.