Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis

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dc.contributor.authorSwarbrick, G. M.
dc.contributor.authorPark, B.
dc.contributor.authorLancioni, C.
dc.contributor.authorNsereko, M.
dc.date.accessioned2022-04-29T10:16:24Z
dc.date.available2022-04-29T10:16:24Z
dc.date.issued2019
dc.description.abstractTuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality. Current tools to identify Mtb-infected individuals, specifically interferon-γ release assays (IGRAs) and the tuberculin skin test (TST), cannot distinguish between asymptomatic Mtb-infected individuals (latent Mtb infection (LTBI)) and those with TB [1]. Advancement of TB diagnostics and their application in TB-endemic settings requires an assay that distinguishes between individuals with LTBI and TB. In this pilot study, we compared the ability of three CD8+ T-cell-based assays to distinguish Ugandan adults with: confirmed pulmonary TB (HIV-uninfected and HIV-infected), LTBI (HIV-uninfected only), and those who are TST-negative (HIV-uninfected only).en_US
dc.identifier.citationLancioni C, Swarbrick GM, Park B, et al. Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis. Eur Respir J 2019; 53: 1802053 [https://doi.org/10.1183/ 13993003.02053-2018].en_US
dc.identifier.urihttps://doi.org/10.1183/ 13993003.02053-2018
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2942
dc.language.isoenen_US
dc.publisherEur Respir Jen_US
dc.subjectCD8+ T-cell epitopesen_US
dc.subjectAdultsen_US
dc.subjectPulmonary tuberculosisen_US
dc.titleRecognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosisen_US
dc.typeArticleen_US
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