Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis
Loading...
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Eur Respir J
Abstract
Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of
morbidity and mortality. Current tools to identify Mtb-infected individuals, specifically interferon-γ release
assays (IGRAs) and the tuberculin skin test (TST), cannot distinguish between asymptomatic Mtb-infected
individuals (latent Mtb infection (LTBI)) and those with TB [1]. Advancement of TB diagnostics and their
application in TB-endemic settings requires an assay that distinguishes between individuals with LTBI and
TB. In this pilot study, we compared the ability of three CD8+ T-cell-based assays to distinguish Ugandan
adults with: confirmed pulmonary TB (HIV-uninfected and HIV-infected), LTBI (HIV-uninfected only),
and those who are TST-negative (HIV-uninfected only).
Description
Keywords
CD8+ T-cell epitopes, Adults, Pulmonary tuberculosis
Citation
Lancioni C, Swarbrick GM, Park B, et al. Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis. Eur Respir J 2019; 53: 1802053 [https://doi.org/10.1183/ 13993003.02053-2018].