Eucalyptus Globulus Ethanol Extract Mitigates Formalin-Induced Acute Cardiotoxicity by Lowering Uric Acid and Lactate Dehydrogenase in Male Swiss Mice
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
The Pharmaceutical and Chemical Journal
Abstract
Background: E.globulus is a medicinal plant which has been shown to possess and exhibit various beneficial properties like anti-inflammatory, anticancer, antibacterial, antiseptic and astringent. Aim: To investigate the cardioprotective properties of E. globulus against formalin-induced acute cardiotoxicity in male Swiss mice and to determine the possible mechanism of its cardioprotective effects. Materials and Methods: Thirty animals were randomly selected into six groups of five animals each as follows; Control group received distil water, extract group (500mg/kg p.o daily), formalin group (20μl/kg i.p) formalin+pro+extract (propranolol, 40mg/kg with E.globulus extract 500mg/kg p.o daily), formalin+gli+extract group (glibenclamide, 8mg/kg with E.globulus extract 500mg/kg p.o daily) formalin+nife+extract group (nifedipine, 10mg/kg with E.globulus extract 500mg/kg p.o daily). The treatment period lasted for two weeks. The mechanism of action was investigated using adrenergic, L type voltage gated calcium channel, and ATP sensitive K+ channel blockers. Results: Cardiotoxicity was assessed by measuring cardiac uric acid, lactate dehydrogenase, urea, and some haematological indices. Treatment with E. globulus (500mg/kg) significantly (p<0.05) decreased the levels of cardiac uric acid and lactate dehydrogenase activity. Conclusion: These results suggest that E. globulus has the potential in preventing the cardiotoxic effects induced by formalin possibly through a mechanism that may involve the adrenergic system and the L-Type Voltage gated Calcium channel.
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Keywords
Formalin, E.globulus, Uric acid and lactate dehydrogenase
Citation
Dangana, E. O., Caleb, J. A., Ozovehe, S. H., Olumorin, O. I., Saidi, O., Nafiu, N. M., & Abayomi, T. (2020). Eucalyptus Globulus Ethanol Extract Mitigates Formalin-Induced Acute Cardiotoxicity by Lowering Uric Acid and Lactate Dehydrogenase in Male Swiss Mice. The Pharmaceutical and Chemical Journal