Molecular Modelling of Potential Candidates for the Treatment of Depression

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dc.contributor.authorSilva, Daniela Rodrigues
dc.contributor.authorBarigye, Stephen J.
dc.contributor.authorSantos-Garcia, Letícia
dc.contributor.authorElaine, Fontes Ferreira da Cunha
dc.date.accessioned2023-02-09T10:51:40Z
dc.date.available2023-02-09T10:51:40Z
dc.date.issued2019
dc.description.abstractA lot of research initiatives in the last decades have been focused on the search of new strategies to treat depression. However, despite the availability of various antidepressants, current treatment is still far from ideal. Unwanted side effects, modest response rates and the slow onset of action are the main shortcomings. As a strategy to improve symptomatic relief and response rates, the dual modulation of the serotonin transporter and the histamine H3 receptor by a single chemical entity has been proposed in the literature. Accordingly, this work aims to elucidate key structural features responsible for the dual inhibitory activity of the hexahydro-pyrrolo-isoquinoline derivatives. For this purpose, two approaches were employed, four-dimensional quantitative structure-activity relationship (4D-QSAR) and molecular docking. The 4D-QSAR models for both receptors allowed the identification of the pharmacophore groups critical for the modelled biological activity, whereas the binding mode of this class of compounds to the human serotonin transporter was assessed by molecular docking. The findings can be applicable to design new antidepressants.en_US
dc.identifier.citationSilva, D. R., Barigye, S. J., Santos‐Garcia, L., & Fontes Ferreira da Cunha, E. (2019). Molecular modelling of potential candidates for the treatment of depression. Molecular informatics, 38(7), 1900024.https://doi.org/10.1002/minf.201900024en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7664
dc.language.isoenen_US
dc.publisherMolecular informaticsen_US
dc.subjectstructure-activity relationshipsen_US
dc.subjectmolecular dockingen_US
dc.subjectdrug designen_US
dc.subjecthexahydro-pyrrolo-isoquinoline derivativesen_US
dc.titleMolecular Modelling of Potential Candidates for the Treatment of Depressionen_US
dc.typeArticleen_US
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