Naphthoquinones from the Roots of Aloe Secundiflora

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dc.contributor.authorIndul, Martha
dc.contributor.authorCheloti, Michael
dc.contributor.authorWasuna, Antonina
dc.contributor.authorWekesa, Ingrid
dc.contributor.authorWanjohi, John M.
dc.contributor.authorByamukama, Robert
dc.contributor.authorHeydenrich, Matthias
dc.contributor.authorMakayoto, Moses
dc.contributor.authorYenesew, Abiy
dc.date.accessioned2021-12-14T10:21:02Z
dc.date.available2021-12-14T10:21:02Z
dc.date.issued2012
dc.description.abstractTwo new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy- 3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene- 1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21– 23 mg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5- hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mg/mL).en_US
dc.identifier.citationInduli, M., Cheloti, M., Wasuna, A., Wekesa, I., Wanjohi, J. M., Byamukama, R., ... & Yenesew, A. (2012). Naphthoquinones from the roots of Aloe secundiflora. Phytochemistry Letters, 5(3), 506-509.http://dx.doi.org/10.1016/j.phytol.2012.04.014en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.phytol.2012.04.014
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/478
dc.language.isoenen_US
dc.publisherPhytochemistry Lettersen_US
dc.subjectAloe secundifloraen_US
dc.subjectAsphodelaceaeen_US
dc.subjectRootsen_US
dc.subjectNaphthoquinoneen_US
dc.subjectAnthraquinoneen_US
dc.subjectAloesaponarin Ien_US
dc.subjectMycobacterium tuberculosisen_US
dc.titleNaphthoquinones from the Roots of Aloe Secundifloraen_US
dc.typeArticleen_US
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